Smoking a pipe or the tobacco?
A pipe is detached, no extra paper, leaves or filter in the mouth, just a literal pipe, sucking in the smoke. It's more a different feeling when breathing it in than a specific tangible difference.
Tobacco wise, finely grounded and very dry tobacco works poorly with pipes in my experience. Burns away too fast and you can accidentally inhale the ashes since they're so fine. stringy not fully dry tobacco works best (don't pack it down into the pipe bowl though)