One game that did this for me recently was TardQuest. From the moment the title screen literally sucked me into the dungeon maze and delivered me in front of a glory hole, I knew that I was at the start of what would be an awakening.
Wading through a confusing dungeon of giant naked rats and grimy sentient refrigerators, dodging giant bowling balls, and constantly looking over my shoulder for the incessant gay vampire who is trying to suck me down, I realized: this is my life. Not as a mere metaphor, but in reality.
The point of the game is to descend further into the "tardspire". Aren't spires supposed to ascend? Usually, but this inversion is intentional. The further down I go, the harder the enemies. The more experience I get. All of the allies that I add are fleeting, getting bitten and slashed away. They're all temporary. Everything is temporary. A fat shifty-eyed mouse cheats me out of my hard-earned money. In this world of unrelenting darkness, I'm feeling around with my anemic green hands, looking for an exit, looking for a path forward, out of this maze, alone.
Never before have I played a game that has both left me questioning if I have latent, hideously gay desires as well as thinking about the last time I cleaned my fridge.
By the way, the Brick of C4 is pretty OP. Check it out:
https://www.newgrounds.com/portal/view/1002337