A Soviet drug better than caffeine!
THE WORKING MAN'S COFFEE!
Bromantane (trade name Ladasten / Ладастен) is a Russian pharmaceutical substance developed in the late 1980s that possesses both stimulant and anxiolytic properties.[2] Although it is a commonly used medication in Russia and surrounding countries, it has not gained widespread recognition or pharmaceutical use in other countries. During the 1996 Olympic Games in Atlanta, 5 different Russian athletes tested positive for bromantane use.[3]
A study conducted on human subjects displayed bromantane's ability to improve endurance and work capacity during stressful and intense conditions.[4] This is because bromantane works as an actoprotector, a substance that makes the body more stable under physical duress without increasing oxygen consumption.[5]
Bromantane is a chemical derivative of adamantane, a polyhedral organic compound containing four fused cyclohexane rings. Bromantane's structure consists of adamantane bound at R2 to a nitrogenous group which is in turn bonded to a phenyl ring substituted at R4 with a bromine group.
Bromantane is atypical among stimulants in the sense that it inhibits serotonin reuptake in addition to inhibiting dopamine reuptake. It also increases levels of norepinephrine, but its means of doing so are unclear.[6] Bromantane's anxiolytic properties are due to its strengthening of GABA-ergic mediation.[5]
Unlike typical stimulants such as amphetamine, bromantane's effects come primarily through the upregulation of tyrosine hydroxylase and aromatic L-amino acid decarboxylase (L-DOPA decarboxylase).[7] Rodent studies have shown a 2-2.5x increase in these enzymes following administration of bromantane, and their upregulation causes a downstream increase in levels of dopamine, serotonin and epinephrine.
Although not relevant at clinical dosages, bromantane has been found to produce anticholinergic effects, including both antimuscarinic and antinicotinic actions, at very high doses in animals.[8][9]
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